| http://purl.uniprot.org/citations/11278251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278251 | http://www.w3.org/2000/01/rdf-schema#comment | "Smad7 is an inhibitory Smad that acts as a negative regulator of signaling by the transforming growth factor-beta (TGF-beta) superfamily proteins. Smad7 is induced by TGF-beta, stably interacts with activated TGF-beta type I receptor (TbetaR-I), and interferes with the phosphorylation of receptor-regulated Smads. Here we show that Smurf1, an E3 ubiquitin ligase for bone morphogenetic protein-specific Smads, also interacts with Smad7 and induces Smad7 ubiquitination and translocation into the cytoplasm. In addition, Smurf1 associates with TbetaR-I via Smad7, with subsequent enhancement of turnover of TbetaR-I and Smad7. These results thus reveal a novel function of Smad7, i.e. induction of degradation of TbetaR-I through recruitment of an E3 ligase to the receptor."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100008200"xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c100008200"xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Imamura T."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Imamura T."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Ebisawa T."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Ebisawa T."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Fukuchi M."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Fukuchi M."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Murakami G."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/author | "Murakami G."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/pages | "12477-12480"xsd:string |
| http://purl.uniprot.org/citations/11278251 | http://purl.uniprot.org/core/pages | "12477-12480"xsd:string |