| http://purl.uniprot.org/citations/11278453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278453 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we report the recurrent proviral activation of the Rap1-specific guanine nucleotide exchange factor CalDAG-GEF I (Kawasaki, H., Springett, G. M., Toki, S., Canales, J. J., Harlan, P., Blumenstiel, J. P., Chen, E. J., Bany, I. A., Mochizuki, N., Ashbacher, A., Matsuda, M., Housman, D. E., and Graybiel, A. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13278-13283; Correction (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 318) gene in BXH-2 acute myeloid leukemia. We also show that CalDAG-GEF I encodes two protein isoforms, a full-length isoform (CalDAG-GEF Ia) and a C-terminally truncated isoform (CalDAG-GEF Ib). Expression of the full-length CalDAG-GEF Ia isoform in Rat2 fibroblasts enhances growth in low serum, whereas expression in Swiss 3T3 cells causes morphological transformation and increased saturation density. In FDCP1 myeloid cells, CalDAG-GEF Ia expression increases growth and saturation density in the presence of the diacylglycerol analogs phorbol 12-myristate 13-acetate (PMA), which activates CalDAG-GEF Ia exchange activity. Likewise, in 32Dcl3 myeloblast cells, CalDAG-GEF Ia expression increases cell adherence to fibronectin in response to PMA and calcium ionophore and allows higher saturation densities and prolonged growth on fibronectin-coated plates. These effects were correlated with increased Rap1, but not Ras, protein activation following PMA and calcium ionophore treatment. Our results suggest that Rap1-GTP delivers signals that favor progression through the cell cycle and morphological transformation. The identification of CalDAG-GEF I as a proto-oncogene in BXH-2 acute myeloid leukemia is the first evidence implicating Rap1 signaling in myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m008970200"xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m008970200"xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Largaespada D.A."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Largaespada D.A."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Morgan K."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Morgan K."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Boss G.R."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Boss G.R."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Acar H."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Acar H."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Dupuy A.J."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Dupuy A.J."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Hasz D.E."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "Hasz D.E."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "von Lintig F.C."xsd:string |
| http://purl.uniprot.org/citations/11278453 | http://purl.uniprot.org/core/author | "von Lintig F.C."xsd:string |