| http://purl.uniprot.org/citations/11278518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278518 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a novel isoform of rat caspase-9 in which the C terminus of full-length caspase-9 is replaced with an alternative peptide sequence. Casp-9-CTD (where CTD is carboxyl-terminal divergent) is expressed in multiple tissues, with the relative highest expression observed in ovary and heart. Casp-9-CTD was found primarily in the cytoplasm and was not detected in the nucleus. Structural predictions suggest that in contrast to full-length caspase-9, casp-9-CTD will not be processed. Our model is supported by reduced protease activity of casp-9-CTD preparations in vitro and by the lack of detectable processing of casp-9-CTD proenzyme or the induction of cell death following transfection into cells. Both neuronal and non-neuronal cell types transfected with casp-9-CTD were resistant to death evoked by trophic factor deprivation or DNA damage. In addition, cytosolic lysates prepared from cells permanently expressing exogenous casp-9-CTD were resistant to caspase induction by cytochrome c in reconstitution assays. Taken together, our observations indicate that casp-9-CTD acts as a dominant-negative variant. Its expression in various tissues indicates a physiological role in regulating cell death."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M009523200"xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m009523200"xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Liu D.X."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Liu D.X."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Franke T.F."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Franke T.F."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Angelastro J.M."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Angelastro J.M."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Greene L.A."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Greene L.A."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Yang A.S."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Moon N.Y."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Moon N.Y."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/author | "Yang A.-S."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/pages | "12190-12200"xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/pages | "12190-12200"xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/title | "Characterization of a novel isoform of caspase-9 that inhibits apoptosis."xsd:string |
| http://purl.uniprot.org/citations/11278518 | http://purl.uniprot.org/core/title | "Characterization of a novel isoform of caspase-9 that inhibits apoptosis."xsd:string |