| http://purl.uniprot.org/citations/11278849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278849 | http://www.w3.org/2000/01/rdf-schema#comment | "Degeneration of neurons in Alzheimer's disease is mediated by beta-amyloid peptide by diverse mechanisms, which include a putative apoptotic component stimulated by unidentified signaling events. This report describes a novel beta-amyloid peptide-binding protein (denoted BBP) containing a G protein-coupling module. BBP is one member of a family of three proteins containing this conserved structure. The BBP subtype bound human beta-amyloid peptide in vitro with high affinity and specificity. Expression of BBP in cell culture induced caspase-dependent vulnerability to beta-amyloid peptide toxicity. Expression of a signaling-deficient dominant negative BBP mutant suppressed sensitivity of human Ntera-2 neurons to beta-amyloid peptide mediated toxicity. These findings suggest that BBP is a target of neurotoxic beta-amyloid peptide and provide new insight into the molecular pathophysiology of Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m011161200"xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m011161200"xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Ryan K."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Ryan K."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Sofia H.J."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Sofia H.J."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Walker S."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Walker S."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Bard J."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Bard J."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Chanda P."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Chanda P."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Edris W."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Edris W."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Smith S.C."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Smith S.C."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Jacobsen J.S."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Jacobsen J.S."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Kajkowski E.M."xsd:string |
| http://purl.uniprot.org/citations/11278849 | http://purl.uniprot.org/core/author | "Kajkowski E.M."xsd:string |