| http://purl.uniprot.org/citations/11278948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278948 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11278948 | http://www.w3.org/2000/01/rdf-schema#comment | "Many aspects of neurogenesis and neuronal differentiation are controlled by basic helix-loop-helix (bHLH) proteins. One such factor is SHARP-1, initially identified on the basis of its sequence similarity to hairy. Unlike hairy, and atypically for bHLHs, SHARP-1 is expressed late in development, suggestive of a role in terminal aspects of differentiation. Nevertheless, the role of SHARP-1 and the identity of its target genes remain unknown. During the course of a one-hybrid screen for transcription factors that bind to regulatory domains of the M1 muscarinic acetylcholine receptor gene, we isolated the bHLH transcription factor SHARP-1. In this study, we investigated the functional role of SHARP-1 in regulating transcription. Fusion proteins of SHARP-1 tethered to the gal4 DNA binding domain repress both basal and activated transcription when recruited to either a TATA-containing or a TATAless promoter. Furthermore, we identified two independent repression domains that operate via distinct mechanisms. Repression by a domain in the C terminus is sensitive to the histone deacetylase inhibitor trichostatin A, whereas repression by the bHLH domain is insensitive to TSA. Furthermore, overexpression of SHARP-1 represses transcription from the M(1) promoter. This study represents the first report to assign a function to, and to identify a target gene for, the bHLH transcription factor SHARP-1."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m011619200"xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m011619200"xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/author | "Roopra A."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/author | "Roopra A."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/author | "Buckley N.J."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/author | "Buckley N.J."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/author | "Garriga-Canut M."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/author | "Garriga-Canut M."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/pages | "14821-14828"xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/pages | "14821-14828"xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/title | "The basic helix-loop-helix protein, SHARP-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/title | "The basic helix-loop-helix protein, SHARP-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11278948 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11278948 |
| http://purl.uniprot.org/citations/11278948 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11278948 |
| http://purl.uniprot.org/citations/11278948 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11278948 |
| http://purl.uniprot.org/citations/11278948 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11278948 |