| http://purl.uniprot.org/citations/11279004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11279004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11279004 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Abl and the Abl-related gene product (Arg) are nonreceptor tyrosine kinases that regulate the actin cytoskeleton of cells by direct association with F-actin and localization to focal contacts. However, the biological significance of this interaction is not known. We show here that transfection of COS-7 cells with a kinase-inactive form of c-Abl (Abl) promotes c-Crk II/p130(CAS) (Crk-CAS) coupling, enhancing cell migration. Moreover, embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg (abl-/-arg-/-) demonstrate increased Crk-CAS coupling and motility. Conversely, expression of a kinase-active form of Abl or reconstitution of abl-/- arg-/-cells with wild-type Abl prevents Crk-CAS coupling and inhibits cell migration. Thus, Abl and Arg kinases play a critical role in preventing cell migration through regulation of Crk and CAS adaptor protein complexes, which are necessary for cell movement."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m100095200"xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m100095200"xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/author | "Kain K.H."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/author | "Kain K.H."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/author | "Klemke R.L."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/author | "Klemke R.L."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/pages | "16185-16192"xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/pages | "16185-16192"xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/title | "Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/title | "Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes."xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11279004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11279004 |
| http://purl.uniprot.org/citations/11279004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11279004 |
| http://purl.uniprot.org/citations/11279004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11279004 |
| http://purl.uniprot.org/citations/11279004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11279004 |
| http://purl.uniprot.org/uniprot/Q4JIM5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11279004 |
| http://purl.uniprot.org/uniprot/P00520 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11279004 |