| http://purl.uniprot.org/citations/11279024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11279024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11279024 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Catenin plays a dual role as a key effector in the regulation of adherens junctions and as a transcriptional coactivator. Phosphorylation of Tyr-654, a residue placed in the last armadillo repeat of beta-catenin, decreases its binding to E-cadherin. We show here that phosphorylation of Tyr-654 also stimulates the association of beta-catenin to the basal transcription factor TATA-binding protein. The structural bases of these different affinities were investigated. Our results indicate that the beta-catenin C-terminal tail interacts with the armadillo repeat domain, hindering the association of the armadillo region to the TATA-binding protein or to E-cadherin. Phosphorylation of beta-catenin Tyr-654 decreases armadillo-C-terminal tail association, uncovering the last armadillo repeats. In a C-terminal-depleted beta-catenin, the presence of a negative charge at Tyr-654 does not affect the interaction of the TATA-binding protein to the armadillo domain. However, in the case of E-cadherin, the establishment of ion pairs dominates its association with beta-catenin, and its binding is greatly dependent on the absence of a negative charge at Tyr-654. Thus, phosphorylation of Tyr-654 blocks the Ecadherin-beta-catenin interaction, even though the steric hindrance of the C-tail is no longer present. These results explain how phosphorylation of beta-catenin in Tyr-654 modifies the tertiary structure of this protein and the interaction with its different partners."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m100194200"xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m100194200"xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Martinez D."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Martinez D."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Castano J."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Castano J."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Dunach M."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Dunach M."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Miravet S."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Miravet S."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Piedra J."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "Piedra J."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "de Herreros A.G."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/author | "de Herreros A.G."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/pages | "20436-20443"xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/pages | "20436-20443"xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/title | "Regulation of beta-catenin structure and activity by tyrosine phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/11279024 | http://purl.uniprot.org/core/title | "Regulation of beta-catenin structure and activity by tyrosine phosphorylation."xsd:string |