| http://purl.uniprot.org/citations/11283159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11283159 | http://www.w3.org/2000/01/rdf-schema#comment | "The physiologic role of L-selectin shedding is unknown. Here, we investigate the effect of L-selectin shedding on firm adhesion and transmigration. In a tumor necrosis factor alpha-induced model of inflammation, inhibition of L-selectin shedding significantly increased firm adhesion and transmigration by a lymphocyte function-associated antigen (LFA)-1 and intercellular adhesion molecule (ICAM)-1-dependent mechanism. We examined the quality of leukocyte rolling and L-selectin-mediated signaling. Blockade of L-selectin shedding significantly reduced the "jerkiness" of leukocyte rolling, defined as the variability of velocity over time. A low level of jerkiness was also observed in the rolling of microbeads conjugated with L-selectin, a model system lacking the mechanism for L-selectin shedding. Inhibition of L-selectin shedding potentiated activation of LFA-1 and Mac-1 induced by L-selectin cross-linking as shown by activation epitope expression and binding of ICAM-1-conjugated beads. We conclude that inhibition of L-selectin shedding increases leukocyte adhesion and transmigration by (a) increasing leukocyte exposure to the inflamed endothelium by decreasing jerkiness and (b) promoting leukocyte activation by outside-in signaling. These observations help to resolve the apparent discrepancy between the minor contribution of L-selectin to rolling and the significant leukocyte recruitment defect in L-selectin knockout mice."xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.193.7.863"xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/author | "Huo Y."xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/author | "Thomas K.L."xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/author | "Ley K."xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/author | "Hafezi-Moghadam A."xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/author | "Prorock A.J."xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/pages | "863-872"xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/title | "L-selectin shedding regulates leukocyte recruitment."xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/11283159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11283159 |
| http://purl.uniprot.org/citations/11283159 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11283159 |
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