| http://purl.uniprot.org/citations/11285280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11285280 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin A is a stable protein in S and G2 phases, but is destabilized when cells enter mitosis and is almost completely degraded before the metaphase to anaphase transition. Microinjection of antibodies against subunits of the anaphase-promoting complex/cyclosome (APC/C) or against human Cdc20 (fizzy) arrested cells at metaphase and stabilized both cyclins A and B1. Cyclin A was efficiently polyubiquitylated by Cdc20 or Cdh1-activated APC/C in vitro, but in contrast to cyclin B1, the proteolysis of cyclin A was not delayed by the spindle assembly checkpoint. The degradation of cyclin B1 was accelerated by inhibition of the spindle assembly checkpoint. These data suggest that the APC/C is activated as cells enter mitosis and immediately targets cyclin A for degradation, whereas the spindle assembly checkpoint delays the degradation of cyclin B1 until the metaphase to anaphase transition. The "destruction box" (D-box) of cyclin A is 10-20 residues longer than that of cyclin B. Overexpression of wild-type cyclin A delayed the metaphase to anaphase transition, whereas expression of cyclin A mutants lacking a D-box arrested cells in anaphase."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.153.1.137"xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/author | "Gannon J."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/author | "Hunt T."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/author | "Peters J.M."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/author | "Gieffers C."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/author | "Geley S."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/author | "Kramer E."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/pages | "137-148"xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/title | "Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint."xsd:string |
| http://purl.uniprot.org/citations/11285280 | http://purl.uniprot.org/core/volume | "153"xsd:string |
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