| http://purl.uniprot.org/citations/11287179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11287179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11287179 | http://www.w3.org/2000/01/rdf-schema#comment | "In a phenotypic screen in mice using a gene trap approach in embryonic stem cells, we have identified a recessive loss-of-function mutation in the mgcRacGAP gene. Maternal protein is present in the oocyte, and mgcRacGAP gene transcription starts at the four-cell stage and persists throughout mouse pre-implantation development. Total mgcRacGAP deficiency results in pre-implantation lethality. Such E3.5 embryos display a dramatic reduction in cell number, but undergo compaction and form a blastocoel. At E3.0-3.5, binucleated blastomeres in which the nuclei are partially interconnected are frequently observed, suggesting that mgcRacGAP is required for normal mitosis and cytokinesis in the pre-implantation embryo. All homozygous mutant blastocysts fail to grow out on fibronectin-coated substrates, but a fraction of them can still induce decidual swelling in vivo. The mgcRacGAP mRNA expression pattern in post-implantation embryos and adult mouse brain suggests a role in neuronal cells. Our results indicate that mgcRacGAP is essential for the earliest stages of mouse embryogenesis, and add evidence that CYK-4-like proteins also play a role in microtubule-dependent steps in the cytokinesis of vertebrate cells. In addition, the severe phenotype of null embryos indicates that mgcRacGAP is functionally non-redundant and cannot be substituted by other GAPs during early cleavage of the mammalian embryo."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4773(01)00279-9"xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4773(01)00279-9"xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Francis A."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Francis A."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Rybin V."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Rybin V."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Huylebroeck D."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Huylebroeck D."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Lonnoy O."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Lonnoy O."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Van de Putte T."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Van de Putte T."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Zwijsen A."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Zwijsen A."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Baekelandt V."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Baekelandt V."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Cozijnsen M."xsd:string |
| http://purl.uniprot.org/citations/11287179 | http://purl.uniprot.org/core/author | "Cozijnsen M."xsd:string |