| http://purl.uniprot.org/citations/11287610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11287610 | http://www.w3.org/2000/01/rdf-schema#comment | "Fms is the receptor for macrophage colony-stimulating factor (M-CSF) and contains intrinsic tyrosine kinase activity. Expression of exogenous Fms in a murine myeloid progenitor cell line, FDC-P1 (FD-Fms), results in M-CSF-dependent growth and macrophage differentiation. Previously, we described a 100-kDa protein that was tyrosine phosphorylated upon M-CSF stimulation of FD-Fms cells. In this report, we identify this 100-kDa protein as the recently cloned scaffolding protein Gab2, and we demonstrate that Gab2 associates with several molecules involved in M-CSF signaling, including Grb2, SHP2, the p85 subunit of phosphatidylinositol 3'-kinase, SHIP, and SHC. Tyrosine phosphorylation of Gab2 in response to M-CSF requires the kinase activity of Fms, but not that of Src. Overexpression of Gab2 in FD-Fms cells enhanced both mitogen-activated protein kinase (MAPK) activity and macrophage differentiation, but reduced proliferation, in response to M-CSF. In contrast, a mutant of Gab2 that is unable to bind SHP2 did not potentiate MAPK activity. Furthermore, overexpression of this mutant in FD-Fms cells inhibited macrophage differentiation and resulted in a concomitant increase in growth potential in response to M-CSF. These data indicate that Gab2 is involved in the activation of the MAPK pathway and that the interaction between Gab2 and SHP2 is essential for the differentiation signal triggered by M-CSF."xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.21.9.3047-3056.2001"xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/author | "Rohrschneider L.R."xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/author | "Jenkins B."xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/author | "Shin J.L."xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/pages | "3047-3056"xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/title | "Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/11287610 | http://purl.uniprot.org/core/volume | "21"xsd:string |
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