| http://purl.uniprot.org/citations/11291046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11291046 | http://www.w3.org/2000/01/rdf-schema#comment | "The etiology of chronic lymphocytic leukemia (CLL) remains unknown, though a genetic susceptibility has been suggested. Results of complete DNA typing of HLA alleles in CLL patients are lacking. We compared HLA class I and class II frequencies in 101 German CLL patients and 157 healthy German controls as determined by PCR-SSP/SSO DNA analysis and serologic typing. The most striking difference was the increased frequency of HLA-DRB4*0103 [relative risk (RR) = 2.74, p < 0.0025] among patients. The presence of alleles HLA-DRB1*0401, HLA-DQB1*0302 and HLA-DPB1*0301 as well as of homozygosity for HLA-DQB1 was also associated with a higher risk for CLL, though none of these differences remained significant after correction for multiple comparisons. No association was found for any HLA class I allele. Haplotype analysis revealed a CLL-specific linkage disequilibrium for HLA-DRB1*0401:DRB4*0103 and HLA-DRB4*0103:DQB1*0302. Our results suggest that CLL could be associated with distinct class II alleles of the Caucasian haplotype HLA-DR4:DR53:DQ8, which has also been related to a susceptibility for several auto-immune diseases. The positive, though weak, association of CLL with HLA-DPB1*0301 might represent an independent susceptibility factor since no linkage disequilibrium existed with any of the other CLL-associated alleles. None of the previously reported associations with HLA class I antigens was confirmed. Our results suggest that factors within or close to the human MHC class II region confer susceptibility to CLL."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.org/dc/terms/identifier | "doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1167>3.0.co;2-a"xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/author | "Langner J."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/author | "Schaaf A."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/author | "Kujat G."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/author | "Machulla H.K."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/author | "Muller L.P."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/author | "Schonermarck U."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/pages | "203-207"xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/title | "Association of chronic lymphocytic leukemia with specific alleles of the HLA-DR4:DR53:DQ8 haplotype in German patients."xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/11291046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11291046 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-11291046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291046 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-11291046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291046 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-11291046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291046 |