| http://purl.uniprot.org/citations/11291049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11291049 | http://www.w3.org/2000/01/rdf-schema#comment | "Breast cancer is the most frequent malignancy among women. Since genetic factors such as BRCA1 and BRCA2 as well as reproductive history constitute only 30% of the cause, environmental exposure may play a significant role in the development of breast cancer. Likewise, the relevant enzymes involved in the biotransformation of xenobiotics (from tobacco smoke, diet or other environmental sources) might play a role in breast carcinogenesis. Since individuals with modified ability to metabolize these carcinogens could have a different risk for breast cancer, we investigated the role of cytochromes P-450 (CYP1A1, CYP2D6), glutathione-S-transferases (GSTM1, GSTT1, GSTP1) and N-acetyltransferases (NAT1, NAT2) gene variants in breast carcinogenesis. A case-control study was conducted on 149 women with breast carcinoma and 207 healthy controls, both of French-Canadian origin. The CYP1A1*4 allele was found to be a significant risk determinant of breast carcinoma (OR = 3.3, 95% CI 1.1-9.7), particularly among post-menopausal women (OR = 4.0, 95% CI 1.2-13.8). The frequency of NAT2 rapid acetylators was increased among smokers (OR = 2.6, 95% CI 0.8-8.2), while the NAT1*10 allele conferred a 4-fold increase in risk among women who consumed well-done meat (OR = 4.4, 95% CI 1.0-18.9). These data suggest that CYP1A1*4, NAT1 and NAT2 variants are involved in the susceptibility to breast carcinoma by modifying the impact of exogenous and/or endogenous exposures."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.org/dc/terms/identifier | "doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1184>3.0.co;2-h"xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Labuda D."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Lacroix A."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Richer C."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Sinnett D."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Perret C."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Ghadirian P."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Gandini S."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Krajinovic M."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/author | "Sinnett H."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/pages | "220-225"xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/title | "Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions."xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/11291049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11291049 |
| http://purl.uniprot.org/citations/11291049 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11291049 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JMS2-mappedCitation-11291049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291049 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JQD8-mappedCitation-11291049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291049 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JQM0-mappedCitation-11291049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291049 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JRJ5-mappedCitation-11291049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291049 |
| http://purl.uniprot.org/uniprot/#_A0A0F7KYR9-mappedCitation-11291049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291049 |
| http://purl.uniprot.org/uniprot/#_A0A0F7KZW3-mappedCitation-11291049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11291049 |