| http://purl.uniprot.org/citations/11292861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11292861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11292861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/11292861 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-alpha subunits are rapidly destroyed by a mechanism that involves ubiquitylation by the von Hippel-Lindau tumor suppressor (pVHL) E3 ligase complex. This process is suppressed by hypoxia and iron chelation, allowing transcriptional activation. Here we show that the interaction between human pVHL and a specific domain of the HIF-1alpha subunit is regulated through hydroxylation of a proline residue (HIF-1alpha P564) by an enzyme we have termed HIF-alpha prolyl-hydroxylase (HIF-PH). An absolute requirement for dioxygen as a cosubstrate and iron as cofactor suggests that HIF-PH functions directly as a cellular oxygen sensor."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1059796"xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1059796"xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "von Kriegsheim A."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "von Kriegsheim A."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Wilson M.I."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Wilson M.I."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Schofield C.J."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Schofield C.J."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Mukherji M."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Mukherji M."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Ratcliffe P.J."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Ratcliffe P.J."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Gaskell S.J."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Gaskell S.J."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Jaakkola P."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Jaakkola P."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Maxwell P.H."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Maxwell P.H."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Pugh C.W."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Pugh C.W."xsd:string |
| http://purl.uniprot.org/citations/11292861 | http://purl.uniprot.org/core/author | "Mole D.R."xsd:string |