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http://purl.uniprot.org/citations/11297731http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11297731http://www.w3.org/2000/01/rdf-schema#comment"Mac1p is a Saccharomyces cerevisiae DNA binding transcription factor that activates genes involved in copper uptake. A copper-induced N-C-terminal intramolecular interaction and copper-independent homodimerization affect its function. Here, we present a functional analysis of Mac1p deletion derivatives that attributes new roles to the second cysteine-rich (REPII) domain of the protein. This domain exhibits the copper-responsive potent transactivation function when assayed independently and, in the context of the entire protein, modulates the efficiency of Mac1p binding to DNA. The efficiency of binding to both copper-response promoter elements can determine the in vivo functionality of Mac1p independent of homodimerization."xsd:string
http://purl.uniprot.org/citations/11297731http://purl.org/dc/terms/identifier"doi:10.1016/s0014-5793(01)02298-0"xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/author"Alexandraki D."xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/author"Voutsina A."xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/author"Fragiadakis G.S."xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/author"Boutla A."xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/pages"38-43"xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/title"The second cysteine-rich domain of Mac1p is a potent transactivator that modulates DNA binding efficiency and functionality of the protein."xsd:string
http://purl.uniprot.org/citations/11297731http://purl.uniprot.org/core/volume"494"xsd:string
http://purl.uniprot.org/citations/11297731http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11297731
http://purl.uniprot.org/citations/11297731http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11297731
http://purl.uniprot.org/uniprot/#_P35192-mappedCitation-11297731http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11297731
http://purl.uniprot.org/uniprot/P35192http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/11297731