| http://purl.uniprot.org/citations/11306707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11306707 | http://www.w3.org/2000/01/rdf-schema#comment | "alpha1-Adrenergic receptor (AR) subtypes in the heart are expressed by myocytes but not by fibroblasts, a feature that distinguishes alpha1-ARs from beta-ARs. Here we studied myocyte-specific expression of alpha1-ARs, focusing on the subtype alpha1C (also called alpha1A), a subtype implicated in cardiac hypertrophic signaling in rat models. We first cloned the mouse alpha1C-AR gene, which consisted of two exons with an 18 kb intron, similar to the alpha1B-AR gene. The receptor coding sequence was >90% homologous to that of rat and human. alpha1C-AR transcription in mouse heart was initiated from a single Inr consensus sequence at -588 from the ATG; this and a putative polyadenylation sequence 8.5 kb 3' could account for the predominant 11 kb alpha1C mRNA in mouse heart. A 5'-nontranscribed fragment of 4.4 kb was active as a promoter in cardiac myocytes but not in fibroblasts. Promoter activity in myocytes required a single muscle CAT (MCAT) element, and this MCAT bound in vitro to recombinant and endogenous transcriptional enhancer factor-1. Thus, alpha1C-AR transcription in cardiac myocytes shares MCAT dependence with other cardiac-specific genes, including the alpha- and beta-myosin heavy chains, skeletal alpha-actin, and brain natriuretic peptide. However, the mouse alpha1C gene was not transcribed in the neonatal heart and was not activated by alpha1-AR and other hypertrophic agonists in rat myocytes, and thus differed from other MCAT-dependent genes and the rat alpha1C gene."xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.org/dc/terms/identifier | "doi:10.1124/mol.59.5.1225"xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/author | "O'Connell T.D."xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/author | "Rokosh D.G."xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/author | "Simpson P.C."xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/name | "Mol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/pages | "1225-1234"xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/title | "Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1)."xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/11306707 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11306707 |
| http://purl.uniprot.org/citations/11306707 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11306707 |
| http://purl.uniprot.org/uniprot/P30051#attribution-D09D4AAD15C4FD46350F7308FAB0441E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11306707 |
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| http://purl.uniprot.org/uniprot/#_E9PVJ5-mappedCitation-11306707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11306707 |
| http://purl.uniprot.org/uniprot/#_E9PVS2-mappedCitation-11306707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11306707 |
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| http://purl.uniprot.org/uniprot/#_E9Q387-mappedCitation-11306707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11306707 |
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| http://purl.uniprot.org/uniprot/#_F6QH05-mappedCitation-11306707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11306707 |
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| http://purl.uniprot.org/uniprot/#_P97718-mappedCitation-11306707 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11306707 |