| http://purl.uniprot.org/citations/11307147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11307147 | http://www.w3.org/2000/01/rdf-schema#comment | "Several polymorphic glutathione-S-transferase (GST) enzymes are involved in the metabolism of a number of potential prostate carcinogens and are thought to engage in the transport of steroid hormones. A case-control study was conducted to determine the association of the GSTP1, GSTM1 and GSTT1 polymorphisms and prostate-cancer risk. The study population consisted of 166 patients with previously untreated, histologically proven prostate cancer and 166 age-matched control patients with benign prostatic hyperplasia (BPH), all of them Caucasians. In the GSTP1 gene, 2 polymorphic alleles, GSTP1*B and GSTP1*C, have been described in addition to the wild-type allele, GSTP1*A. Both polymorphic GSTP1 alleles have an A-to-G transition in exon 5, causing an isoleucine-to-valine change. The GSTP1*C allele has an additional transition from C to T. For GSTM1 as well as GSTT1, the polymorphic allele is a deletion of the gene. The proportion of individuals homozygous for the GSTP1 variant alleles (GSTP1*B/*B, GSTP1*B/*C and GSTP1*C/*C) was significantly lower in prostate-cancer patients (4.8%) than in BPH controls (14.5%), and the odds ratio (OR) was 0.24 [95% confidence interval (CI) = 0.09-0.61). The heterozygous genotypes (GSTP1*A/*B and GSTP1*A/*C) were also lower in the cancer group, though this was not significant. On the contrary, no significant effect on prostate-cancer risk was detectable for either GSTM1 (OR = 0.86, 95% CI = 0.55-1.36) or GSTT1 (OR = 0.78, 95% CI = 0.43-1.42). Of the polymorphic GSTs, GSTP1 is the most interesting candidate as a biomarker for prostate-cancer risk as we found a 76% reduced risk in men homozygous for the polymorphic GSTP1 alleles compared to those with wild-type GSTP1."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.org/dc/terms/identifier | "doi:10.1002/1097-0215(20010520)95:3<152::aid-ijc1026>3.0.co;2-s"xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Micksche M."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Hinteregger S."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Bernhofer G."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Gsur A."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Haidinger G."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Madersbacher S."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Marberger M."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Schatzl G."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/author | "Vutuc C."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/pages | "152-155"xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/title | "Polymorphisms of glutathione-S-transferase genes (GSTP1, GSTM1 and GSTT1) and prostate-cancer risk."xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/11307147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11307147 |
| http://purl.uniprot.org/citations/11307147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11307147 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JMS2-mappedCitation-11307147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11307147 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JQD8-mappedCitation-11307147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11307147 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JQM0-mappedCitation-11307147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11307147 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JRJ5-mappedCitation-11307147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11307147 |
| http://purl.uniprot.org/uniprot/#_A0A0M5MRY8-mappedCitation-11307147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11307147 |
| http://purl.uniprot.org/uniprot/#_A0A0M4UT83-mappedCitation-11307147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11307147 |