| http://purl.uniprot.org/citations/11309420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11309420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11309420 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe here a novel sarcomeric 145-kD protein, myopalladin, which tethers together the COOH-terminal Src homology 3 domains of nebulin and nebulette with the EF hand motifs of alpha-actinin in vertebrate Z-lines. Myopalladin's nebulin/nebulette and alpha-actinin-binding sites are contained in two distinct regions within its COOH-terminal 90-kD domain. Both sites are highly homologous with those found in palladin, a protein described recently required for actin cytoskeletal assembly (Parast, M.M., and C.A. Otey. 2000. J. Cell Biol. 150:643-656). This suggests that palladin and myopalladin may have conserved roles in stress fiber and Z-line assembly. The NH(2)-terminal region of myopalladin specifically binds to the cardiac ankyrin repeat protein (CARP), a nuclear protein involved in control of muscle gene expression. Immunofluorescence and immunoelectron microscopy studies revealed that myopalladin also colocalized with CARP in the central I-band of striated muscle sarcomeres. Overexpression of myopalladin's NH(2)-terminal CARP-binding region in live cardiac myocytes resulted in severe disruption of all sarcomeric components studied, suggesting that the myopalladin-CARP complex in the central I-band may have an important regulatory role in maintaining sarcomeric integrity. Our data also suggest that myopalladin may link regulatory mechanisms involved in Z-line structure (via alpha-actinin and nebulin/nebulette) to those involved in muscle gene expression (via CARP)."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.153.2.413"xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.153.2.413"xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Yamasaki R."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Yamasaki R."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Bang M.-L."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Bang M.-L."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Granzier H."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Granzier H."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Gregorio C.C."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Gregorio C.C."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Labeit S."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Labeit S."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "McElhinny A.S."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "McElhinny A.S."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Sorimachi H."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Sorimachi H."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Geach A.J."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Geach A.J."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Mudry R.E."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Mudry R.E."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Trombitas K."xsd:string |
| http://purl.uniprot.org/citations/11309420 | http://purl.uniprot.org/core/author | "Trombitas K."xsd:string |