| http://purl.uniprot.org/citations/11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11309664 | http://www.w3.org/2000/01/rdf-schema#comment | "The Oct-4 gene encodes a transcription factor that is specifically expressed in embryonic stem cells and germ cells of the mouse embryo. Cells that differentiate into somatic tissues lose Oct-4 expression. Regulation of Oct-4 gene transcription involves a TATA-less minimal promoter and two upstream elements: the proximal (PE) and distal enhancers (DE). We report here the nucleotide sequence of the 5' upstream regulatory regions of the human and murine Oct-4 genes. A comparative alignment analysis between these regions and those of the bovine Oct-4 ortholog reveals four conserved regions of homology (CR 1 to 4) between these species (66-94% conservation). The 1A sequence within the mouse PE is located approximately half-way between CR 2 and CR 3. A putative Sp1/Sp3 binding site and the overlapping hormone responsive element (HRE) in CR1 are identical in all three species. A high number of CCC(A/T)CCC motifs exhibit various levels of homology in these upstream regions. We discuss the importance of these and other sequences and present candidate factors that may bind and regulate Oct-4 gene expression."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.org/dc/terms/identifier | "doi:10.1007/s003350010279"xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/author | "Orlova I."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/author | "Bauer A."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/author | "Nordhoff V."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/author | "Scholer H.R."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/author | "Hubner K."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/author | "Malapetsa A."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/name | "Mamm Genome"xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/pages | "309-317"xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/title | "Comparative analysis of human, bovine, and murine Oct-4 upstream promoter sequences."xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/11309664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11309664 |
| http://purl.uniprot.org/citations/11309664 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11309664 |
| http://purl.uniprot.org/uniprot/#_A0A2Z6DUK5-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/#_A0A2I6EDI9-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/#_A0A2I6EDJ6-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/#_G3UZG9-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/#_E2JL30-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/#_E2JL33-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/#_E2JL35-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/#_P20263-mappedCitation-11309664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11309664 |
| http://purl.uniprot.org/uniprot/E2JL35 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11309664 |