| http://purl.uniprot.org/citations/11313972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11313972 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11313972 | http://www.w3.org/2000/01/rdf-schema#comment | "The translocation t(11;19) is frequently found in acute leukemia in infants. This event truncates the proto-oncogene MLL and fuses the 5' end of MLL in frame with the ENL gene. ENL contributes a crucial protein-protein interaction domain to the resulting oncoprotein MLL-ENL. Here we show by yeast two-hybrid assays, GST-pull-down experiments and in a far western blot analysis that this domain is necessary and sufficient to recruit a novel member of the human Polycomb protein family (hPc3). hPc3 RNA was detected throughout the human hematopoietic system. Similar to other Polycomb proteins hPc3 acts as a transcriptional repressor. The ENL-hPc3 interaction was verified by mutual co-precipitation of the proteins from cell extracts. ENL and hPc3 tagged with fluorescent proteins co-localized in living cells in a nuclear dot pattern. An internal region of hPc3 was responsible for binding to ENL. Finally, hPc3 binds to the C-terminus of AF9, another common MLL fusion partner. The recruitment of a repressive function by ENL opens up a new insight into a possible mechanism of leukemogenesis by the fusion protein MLL-ENL."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1204108"xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1204108"xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Slany R.K."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Slany R.K."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Birke M."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Birke M."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Garcia-Cuellar M.P."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Garcia-Cuellar M.P."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Schreiner S.A."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Schreiner S.A."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Winkler T.H."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Winkler T.H."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Zilles O."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/author | "Zilles O."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/pages | "411-419"xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/pages | "411-419"xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/title | "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3."xsd:string |
| http://purl.uniprot.org/citations/11313972 | http://purl.uniprot.org/core/title | "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3."xsd:string |