| http://purl.uniprot.org/citations/11316796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11316796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11316796 | http://www.w3.org/2000/01/rdf-schema#comment | "The CCCH zinc finger protein PIE-1 is an essential regulator of germ cell fate that segregates with the germ lineage during the first cleavages of the Caenorhabditis elegans embryo. We have shown previously that one function of PIE-1 is to inhibit mRNA transcription. Here we show that PIE-1 has a second function in germ cells; it is required for efficient expression of the maternally encoded Nanos homolog NOS-2. This second function is genetically separable from PIE-1's inhibitory effect on transcription. A mutation in PIE-1's second CCCH finger reduces NOS-2 expression without affecting transcriptional repression and causes primordial germ cells to stray away from the somatic gonad, occasionally exiting the embryo entirely. Our results indicate that PIE-1 promotes germ cell fate by two independent mechanisms as follows: (1) inhibition of transcription, which blocks zygotic programs that drive somatic development, and (2) activation of protein expression from nos-2 and possibly other maternal RNAs, which promotes primordial germ cell development."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.876201"xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.876201"xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Dunn M.A."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Dunn M.A."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Subramaniam K."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Subramaniam K."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Tenenhaus C."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/author | "Tenenhaus C."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/pages | "1031-1040"xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/pages | "1031-1040"xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/title | "PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/title | "PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/11316796 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11316796 |
| http://purl.uniprot.org/citations/11316796 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11316796 |