| http://purl.uniprot.org/citations/11322507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11322507 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11322507 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously reported the cloning and characterization of a new orphan G-protein-coupled receptor (GPC-R), the growth hormone secretagogue receptor (GHS-R), and shown that this receptor mediates the activity of the growth hormone-releasing peptides (GHRPs) and nonpeptide ligands such as L-692,429 and MK-0677. Because the GHS-R obviously does not belong to any of the known GPC-R subfamilies, we searched for GHS-R family members by screening a human genomic library using low-stringency hybridization and screening a Pufferfish genomic library. The Pufferfish was selected because of its compact genome. From the human genomic library, a homolog, GPR38, with 52% identity to the GHS-R was isolated. From the Pufferfish library, three family members were isolated. The Pufferfish gene having 58% identity to the GHS-R, on expression in HEK293 cells, was activated with GHRP-6 and MK-0677. These results indicate that the GHS-R has been conserved for at least 400 million years and that the Pufferfish genome is appropriate for isolation of GHS-R family members. In our search for endogenous ligands for the orphan receptors GHS-R and GPR38, we showed that adenosine is a partial agonist of the GHS-R and that motilin is the endogenous ligand for GPR38. We also confirmed that the endogenous ligand ghrelin is a full agonist of the GHS-R."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.org/dc/terms/identifier | "doi:10.1385/endo:14:1:009"xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.org/dc/terms/identifier | "doi:10.1385/endo:14:1:009"xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Griffin P.R."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Griffin P.R."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Tan C.P."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Tan C.P."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Leonard R."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Leonard R."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Howard A.D."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Howard A.D."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Feighner S.D."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Feighner S.D."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Smith R.G."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Smith R.G."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Palyha O.C."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Palyha O.C."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Bailey A.R.T."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Bailey A.R.T."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Mckee K.K."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Mckee K.K."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Pong S.-S."xsd:string |
| http://purl.uniprot.org/citations/11322507 | http://purl.uniprot.org/core/author | "Pong S.-S."xsd:string |