| http://purl.uniprot.org/citations/11331592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11331592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11331592 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the isolation of TRIP-Br1, a transcriptional regulator that interacts with the PHD-bromodomain of co-repressors of Krüppel-associated box (KRAB)-mediated repression, KRIP-1(TIF1beta) and TIF1alpha, as well as the co-activator/adaptor p300/CBP. TRIP-Br1 and the related protein TRIP-Br2 possess transactivation domains. Like MDM2, which has a homologous transactivation domain, TRIP-Br proteins functionally contact DP-1, stimulating E2F-1/DP-1 transcriptional activity. KRIP-1 potentiates TRIP-Br protein co-activation of E2F-1/DP-1. TRIP-Br1 is a component of a multiprotein complex containing E2F-1 and DP-1. Co-expression of the retinoblastoma gene product (RB) abolishes baseline E2F-1/DP-1 transcriptional activity as well as TRIP-Br/KRIP-1 co-activation, both of which are restored by the adenovirus E1A oncoprotein. These features suggest that TRIP-Br proteins function at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. TRIP-Br1 is identical to the cyclin-dependent kinase 4 (cdk4)-binding protein p34(SEI-1), which renders the activity of cyclin D/cdk4 resistant to the inhibitory effect of p16(INK4a) during late G(1). TRIP-Br1(p34(SEI-1)) is differentially overexpressed during the G(1) and S phases of the cell cycle, consistent with a dual role for TRIP-Br1(p34(SEI-1)) in the regulation of cell cycle progression through sequential effects on the transcriptional activity of E2F-responsive promoters during G(1) and S phases."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.9.2273"xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.9.2273"xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Yang C.M."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Yang C.M."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Bonventre J.V."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Bonventre J.V."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Hentschel D.M."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Hentschel D.M."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "O'Leary E."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "O'Leary E."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Sim K.G."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Sim K.G."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Hsu S.-I."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/author | "Hsu S.-I."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/pages | "2273-2285"xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/pages | "2273-2285"xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/title | "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1."xsd:string |
| http://purl.uniprot.org/citations/11331592 | http://purl.uniprot.org/core/title | "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1."xsd:string |