| http://purl.uniprot.org/citations/11333232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11333232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11333232 | http://www.w3.org/2000/01/rdf-schema#comment | "The genome of Caenorhabditis elegans harbors two genes for G-protein beta-subunits. Here, we describe the characterization of the second G-protein beta-subunit gene gpb-2. In contrast to gpb-1, gpb-2 is not an essential gene even though, like gpb-1, gpb-2 is expressed during development, in the nervous system, and in muscle cells. A loss-of-function mutation in gpb-2 produces a variety of behavioral defects, including delayed egg laying and reduced pharyngeal pumping. Genetic analysis shows that GPB-2 interacts with the GOA-1 (homologue of mammalian G(o)alpha) and EGL-30 (homologue of mammalian G(q)alpha) signaling pathways. GPB-2 is most similar to the divergent mammalian Gbeta5 subunit, which has been shown to mediate a specific interaction with a Ggamma-subunit-like (GGL) domain of RGS proteins. We show here that GPB-2 physically and genetically interacts with the GGL-containing RGS proteins EGL-10 and EAT-16. Taken together, our results suggest that GPB-2 works in concert with the RGS proteins EGL-10 and EAT-16 to regulate GOA-1 (G(o)alpha) and EGL-30 (G(q)alpha) signaling."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/158.1.221"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/158.1.221"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "Cuppen E."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "Cuppen E."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "Plasterk R.H.A."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "Plasterk R.H.A."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "Simmer F."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "Simmer F."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "van Der Linden A.M."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/author | "van Der Linden A.M."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/pages | "221-235"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/pages | "221-235"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/title | "The G protein beta subunit gpb-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G protein signaling proteins egl-10 and eat-16."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/title | "The G protein beta subunit gpb-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G protein signaling proteins egl-10 and eat-16."xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/volume | "158"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://purl.uniprot.org/core/volume | "158"xsd:string |
| http://purl.uniprot.org/citations/11333232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11333232 |
| http://purl.uniprot.org/citations/11333232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11333232 |