| http://purl.uniprot.org/citations/11336508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11336508 | http://www.w3.org/2000/01/rdf-schema#comment | "During hindbrain development, segmental regulation of the paralogous Hoxa2 and Hoxb2 genes in rhombomeres (r) 3 and 5 involves Krox20-dependent enhancers that have been conserved during the duplication of the vertebrate Hox clusters from a common ancestor. Examining these evolutionarily related control regions could provide important insight into the degree to which the basic Krox20-dependent mechanisms, cis-regulatory components, and their organization have been conserved. Toward this goal we have performed a detailed functional analysis of a mouse Hoxa2 enhancer capable of directing reporter expression in r3 and r5. The combined activities of five separate cis-regions, in addition to the conserved Krox20 binding sites, are involved in mediating enhancer function. A CTTT (BoxA) motif adjacent to the Krox20 binding sites is important for r3/r5 activity. The BoxA motif is similar to one (Box1) found in the Hoxb2 enhancer and indicates that the close proximity of these Box motifs to Krox20 sites is a common feature of Krox20 targets in vivo. Two other rhombomeric elements (RE1 and RE3) are essential for r3/r5 activity and share common TCT motifs, indicating that they interact with a similar cofactor(s). TCT motifs are also found in the Hoxb2 enhancer, suggesting that they may be another common feature of Krox20-dependent control regions. The two remaining Hoxa2 cis-elements, RE2 and RE4, are not conserved in the Hoxb2 enhancer and define differences in some of components that can contribute to the Krox20-dependent activities of these enhancers. Furthermore, analysis of regulatory activities of these enhancers in a Krox20 mutant background has uncovered differences in their degree of dependence upon Krox20 for segmental expression. Together, this work has revealed a surprising degree of complexity in the number of cis-elements and regulatory components that contribute to segmental expression mediated by Krox20 and sheds light on the diversity and evolution of Krox20 target sites and Hox regulatory elements in vertebrates."xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.2001.0197"xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/author | "Krumlauf R."xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/author | "Maconochie M.K."xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/author | "Manzanares M."xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/author | "Marshall H."xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/author | "Nonchev S."xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/pages | "468-481"xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/title | "Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development."xsd:string |
| http://purl.uniprot.org/citations/11336508 | http://purl.uniprot.org/core/volume | "233"xsd:string |
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