| http://purl.uniprot.org/citations/11340171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11340171 | http://www.w3.org/2000/01/rdf-schema#comment | "CCAAT/enhancer binding protein alpha (C/EBPalpha) is an integral factor in the granulocytic developmental pathway, as myeloblasts from C/EBPalpha-null mice exhibit an early block in differentiation. Since mice deficient for known C/EBPalpha target genes do not exhibit the same block in granulocyte maturation, we sought to identify additional C/EBPalpha target genes essential for myeloid cell development. To identify such genes, we used both representational difference analysis and oligonucleotide array analysis with RNA derived from a C/EBPalpha-inducible myeloid cell line. From each of these independent screens, we identified c-Myc as a C/EBPalpha negatively regulated gene. We mapped an E2F binding site in the c-Myc promoter as the cis-acting element critical for C/EBPalpha negative regulation. The identification of c-Myc as a C/EBPalpha target gene is intriguing, as it has been previously shown that down-regulation of c-Myc can induce myeloid differentiation. Here we show that stable expression of c-Myc from an exogenous promoter not responsive to C/EBPalpha-mediated down-regulation forces myeloblasts to remain in an undifferentiated state. Therefore, C/EBPalpha negative regulation of c-Myc is critical for allowing early myeloid precursors to enter a differentiation pathway. This is the first report to demonstrate that C/EBPalpha directly affects the level of c-Myc expression and, thus, the decision of myeloid blasts to enter into the granulocytic differentiation pathway."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.21.11.3789-3806.2001"xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/author | "Iwama A."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/author | "Johansen L.M."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/author | "Golub T.R."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/author | "Felsher D.W."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/author | "Lodie T.A."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/pages | "3789-3806"xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/title | "c-Myc is a critical target for c/EBPalpha in granulopoiesis."xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11340171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11340171 |
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