| http://purl.uniprot.org/citations/11344224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11344224 | http://www.w3.org/2000/01/rdf-schema#comment | "This study was performed to test the hypothesis that genetic variation in the promoter of the glucose transporter 2 (GLUT2) might predispose to prediabetic phenotypes or type 2 diabetes. A total of 1611 bp comprising the minimal promoter region of the GLUT2 gene were examined by combined single-strand conformational polymorphism and heteroduplex analysis followed by direct sequencing of identified variants on genomic DNA from 96 randomly recruited Danish type 2 diabetic patients. We identified 4 nucleotide variants, -447g-->a, -149c-->a, -122t-->c, and -44g-->a. None of the variants were positioned in known or presumed transcription factor binding sites, TATA-box, or transcriptional start site. Association studies of the -149c-->a, -122t-->c, and -44g-->a variants revealed that the variants were as prevalent in 320 type 2 diabetic patients [11.0% (95% confidence interval, 8.4-13.6), 9.8% (7.4-12.2), and 29.0% (24.4-33.6), respectively] as in 241 age-matched glucose-tolerant subjects [13.1% (9.8-16.4), 11.2% (8.3-14.1), and 33.4% (28.8-38.0), respectively]. The -447g-->a mutation was only identified in a single diabetic patient and did not show cosegregation with diabetes in the family of the proband. The three common variants showed in a primary genotype-phenotype study comprising 241 glucose-tolerant middle-aged subjects association to increased plasma glucose levels during an oral glucose tolerance test. However, this result could not be replicated in a second sample of 298 60-yr-old glucose-tolerant subjects. In conclusion, we found no evidence supporting the hypothesis that genetic variability in the minimal promoter of the GLUT2 is associated with type 2 diabetes or prediabetic phenotypes in the Danish population."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.org/dc/terms/identifier | "doi:10.1210/jcem.86.5.7499"xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Hansen T."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Pedersen O."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Urhammer S.A."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Borch-Johnsen K."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Drivsholm T."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Jensen N.M."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Moller A.M."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/author | "Pildal J."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/pages | "2181-2186"xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/title | "Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus."xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/11344224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11344224 |
| http://purl.uniprot.org/citations/11344224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11344224 |
| http://purl.uniprot.org/uniprot/#_P11168-mappedCitation-11344224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11344224 |
| http://purl.uniprot.org/uniprot/#_Q6PAU8-mappedCitation-11344224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11344224 |
| http://purl.uniprot.org/uniprot/P11168 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11344224 |
| http://purl.uniprot.org/uniprot/Q6PAU8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11344224 |