| http://purl.uniprot.org/citations/11350920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11350920 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-3 plays a critical role in a proteolytic cascade within the apoptosis signal pathway; this enzyme is commonly activated by numerous death signals and cleaves a variety of important cellular proteins. Using caspase-3-deficient MCF7 cells and clones stably transfected with the caspase-3 gene (MCF7/Casp3), we evaluated the role of caspase-3 in Bax-induced apoptosis. Bax overexpression induced cell death in both parental MCF7 cells and MCF7/Casp3 cells. The introduction of the caspase-3 gene did not change the rate of cell death. Caspase-3-deficient parental MCF7 cells, however, failed to undergo morphological nuclear and DNA fragmentation, whereas MCF7/casp3 cells displayed intact nuclear dismantling and DNA fragmentation. Caspase-3 deficiency, however, did not affect Bax-induced levels of poly(ADP-ribose) polymerase cleavage, caspase-6 activation, and lamin B cleavage. Together, these results suggest that a deficit in caspase-3 is not sufficient to block Bax-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/author | "Honda T."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/author | "Roth J.A."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/author | "Fang B."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/author | "Kagawa S."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/author | "McDonnell T.J."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/author | "Swisher S.G."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/name | "Clin Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/pages | "1474-1480"xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/title | "Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death."xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/11350920 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11350920 |
| http://purl.uniprot.org/citations/11350920 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11350920 |
| http://purl.uniprot.org/uniprot/Q07812#attribution-65620C05D2534F355872DF8E9FFEABE5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11350920 |