| http://purl.uniprot.org/citations/11350980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11350980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11350980 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitously expressed c-Abl tyrosine kinase is activated in the response of cells to genotoxic and oxidative stress. The present study demonstrates that reactive oxygen species (ROS) induce targeting of c-Abl to mitochondria. We show that ROS-induced localization of c-Abl to mitochondria is dependent on activation of protein kinase C (PKC)delta and the c-Abl kinase function. Targeting of c-Abl to mitochondria is associated with ROS-induced loss of mitochondrial transmembrane potential. The results also demonstrate that c-Abl is necessary for ROS-induced depletion of ATP and the activation of a necrosis-like cell death. These findings indicate that the c-Abl kinase targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m101414200"xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m101414200"xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Bharti A."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Bharti A."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Kharbanda S."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Kharbanda S."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Raina D."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Raina D."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Mishra N.C."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Mishra N.C."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Saxena S."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/author | "Saxena S."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/pages | "17281-17285"xsd:string |
| http://purl.uniprot.org/citations/11350980 | http://purl.uniprot.org/core/pages | "17281-17285"xsd:string |