| http://purl.uniprot.org/citations/11352562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11352562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11352562 | http://www.w3.org/2000/01/rdf-schema#comment | "Transgenic mice expressing c-myc under the control of the albumin promoter and enhancer develop liver tumors and have served as a useful model for studying the progression of hepatocarcinogenesis. The chromosomes of one line of c-myc transgenic mice carry the reciprocal translocation t(5;6)(G1;F2) adjacent to the transgene insertion site on the 5G1-ter segment translocated to chromosome 6. To characterize the genomic alterations in the c-myc transgenic animals, we have cloned the mouse DNA flanking the transgene array. By linkage mapping, the transgene integration site was localized to the region of distal chromosome 5 syntenic to the region on human chromosome 7q11.23 that is hemizgygously deleted in Williams-Beuren syndrome, a multisystemic developmental disorder. Comparison of the genomic DNA structure in wildtype and transgenic mice revealed that the transgene integration had induced an approximately 40-kb deletion, starting downstream of the Cyln2 gene and including the first exon of the Gtf2ird1 gene. Gtf2ird1 encodes a polypeptide related to general transcription factor TFII-I, and it is the mouse orthologue of GTF2IRD1 (WBSCR11), one of the genes commonly deleted in Williams-Beuren syndrome patients. Loss of the 5' end of the Gtf2ird1 gene resulted in greatly reduced expression of Gtf2ird1 mRNA in mice homozygous for the transgene."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.2001.6507"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.2001.6507"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Popescu N.C."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Popescu N.C."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Thorgeirsson S.S."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Thorgeirsson S.S."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Durkin M.E."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Durkin M.E."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Keck-Waggoner C.L."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/author | "Keck-Waggoner C.L."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/pages | "20-27"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/pages | "20-27"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/title | "Integration of a c-myc transgene results in disruption of the mouse Gtf2ird1 gene, the homologue of the human GTF2IRD1 gene hemizygously deleted in Williams-Beuren syndrome."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/title | "Integration of a c-myc transgene results in disruption of the mouse Gtf2ird1 gene, the homologue of the human GTF2IRD1 gene hemizygously deleted in Williams-Beuren syndrome."xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/11352562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11352562 |
| http://purl.uniprot.org/citations/11352562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11352562 |