| http://purl.uniprot.org/citations/11353838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11353838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11353838 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously we have characterized type IB DNA topoisomerase V (topo V) in the hyperthermophile Methanopyrus kandleri. The enzyme has a powerful topoisomerase activity and is abundant in M. kandleri. Here we report two characterizations of topo V. First, we found that its N-terminal domain has sequence homology with both eukaryotic type IB topoisomerases and the integrase family of tyrosine recombinases. The C-terminal part of the sequence includes 12 repeats, each repeat consisting of two similar but distinct helix-hairpin-helix motifs; the same arrangement is seen in recombination protein RuvA and mammalian DNA polymerase beta. Second, on the basis of sequence homology between topo V and polymerase beta, we predict and demonstrate that topo V possesses apurinic/apyrimidinic (AP) site-processing activities that are important in base excision DNA repair: (i) it incises the phosphodiester backbone at the AP site, and (ii) at the AP endonuclease cleaved AP site, it removes the 5' 2-deoxyribose 5-phosphate moiety so that a single-nucleotide gap with a 3'-hydroxyl and 5'-phosphate can be filled by a DNA polymerase. Topo V is thus the prototype for a new subfamily of type IB topoisomerases and is the first example of a topoisomerase with associated DNA repair activities."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.111040498"xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.111040498"xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Kozyavkin S.A."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Kozyavkin S.A."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Slesarev A.I."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Slesarev A.I."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Belova G.I."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Belova G.I."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Lake J.A."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Lake J.A."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Prasad R."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Prasad R."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Wilson S.H."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/author | "Wilson S.H."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/pages | "6015-6020"xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/pages | "6015-6020"xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/title | "A type IB topoisomerase with DNA repair activities."xsd:string |
| http://purl.uniprot.org/citations/11353838 | http://purl.uniprot.org/core/title | "A type IB topoisomerase with DNA repair activities."xsd:string |