DESCRIBE <http://purl.uniprot.org/citations/11357483>

Subject	Predicate	Object
http://purl.uniprot.org/citations/11357483	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11357483	http://www.w3.org/2000/01/rdf-schema#comment	" Aims/hypothesis Recent studies have shown the anti diabetic effects of oral sodium tungstate treatment in several animal models of diabetes based on short-term experiments. In this study, we examined the effectiveness of long-term tungstate treatment of streptozotocin-induced-diabetic rats. Methods Tungstate was administered to the drinking water of rats for eight months. Results The treatment resulted in a reduction in serum glucose concentrations in diabetic rats, but no change in glycaemia was detected in healthy rats. Alterations in the hepatic glucose metabolism due to diabetes were almost completely counteracted by tungstate treatment. The partial recovery of glucokinase activity, not found in diabetic animals, normalised glycogen and glucose 6-phosphate concentrations. Tungstate treatment also restored pyruvate kinase activity and fructose 2,6-bisphosphate concentrations. In healthy rats, tungstate treatment did not modify the majority of the hepatic parameters studied. Moreover, tungstate treatment prevented diabetes-induced morphological changes in the kidney and ocular lens and also reduced mortality. Furthermore, no hypoglycaemic episodes or undesirable side effects were observed in treated diabetic or healthy rats. In addition, there is no evidence of intolerance developing after prolonged use. Conclusion/interpretation Tungstate could play a helpful part in the long-term treatment of diabetes."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.org/dc/terms/identifier	"doi:10.1007/s001250100479"xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/author	"Gomis R."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/author	"Guinovart J.J."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/author	"Domingo M."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/author	"Rodriguez-Gil J.E."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/author	"Barbera A."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/author	"Gomis R.R."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/author	"Prats N."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/date	"2001"xsd:gYear
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/name	"Diabetologia"xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/pages	"507-513"xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/title	"Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term study."xsd:string
http://purl.uniprot.org/citations/11357483	http://purl.uniprot.org/core/volume	"44"xsd:string
http://purl.uniprot.org/citations/11357483	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/11357483
http://purl.uniprot.org/citations/11357483	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/11357483
http://purl.uniprot.org/uniprot/P12928#attribution-0D30F836D45230999BF3BBB270122A86	http://purl.uniprot.org/core/source	http://purl.uniprot.org/citations/11357483
http://purl.uniprot.org/uniprot/#_A0A0H2UI07-mappedCitation-11357483	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/11357483
http://purl.uniprot.org/uniprot/#_B1WBN9-mappedCitation-11357483	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/11357483
http://purl.uniprot.org/uniprot/#_P12928-mappedCitation-11357483	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/11357483
http://purl.uniprot.org/uniprot/A0A0H2UI07	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/11357483
http://purl.uniprot.org/uniprot/P12928	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/11357483
http://purl.uniprot.org/uniprot/B1WBN9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/11357483