| http://purl.uniprot.org/citations/11358867 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11358867 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammals express four highly conserved TEAD/TEF transcription factors that bind the same DNA sequence, but serve different functions during development. TEAD-2/TEF-4 protein purified from mouse cells was associated predominantly with a novel TEAD-binding domain at the amino terminus of YAP65, a powerful transcriptional coactivator. YAP65 interacted specifically with the carboxyl terminus of all four TEAD proteins. Both this interaction and sequence-specific DNA binding by TEAD were required for transcriptional activation in mouse cells. Expression of YAP in lymphocytic cells that normally do not support TEAD-dependent transcription (e.g., MPC11) resulted in up to 300-fold induction of TEAD activity. Conversely, TEAD overexpression squelched YAP activity. Therefore, the carboxy-terminal acidic activation domain in YAP is the transcriptional activation domain for TEAD transcription factors. However, whereas TEAD was concentrated in the nucleus, excess YAP65 accumulated in the cytoplasm as a complex with the cytoplasmic localization protein, 14-3-3. Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals."xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.888601"xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/author | "Shu H."xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/author | "Vassilev A."xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/author | "DePamphilis M.L."xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/author | "Kaneko K.J."xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/pages | "1229-1241"xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/title | "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm."xsd:string |
| http://purl.uniprot.org/citations/11358867 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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