| http://purl.uniprot.org/citations/11368322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11368322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11368322 | http://www.w3.org/2000/01/rdf-schema#comment | "The alpha2beta1 integrin is a major collagen receptor that plays an essential role in the adhesion of normal and tumor cells to the extracellular matrix. Here we describe the isolation of a novel metalloproteinase/disintegrin, which is a potent inhibitor of the collagen binding to alpha2beta1 integrin. This 55-kDa protein (alternagin) and its disintegrin domain (alternagin-C) were isolated from Bothrops alternatus snake venom. Amino acid sequencing of alternagin-C revealed the disintegrin structure. Alternagin and alternagin-C inhibit collagen I-mediated adhesion of K562-alpha2beta1-transfected cells. The IC50 was 134 and 100 nM for alternagin and alternagin-C, respectively. Neither protein interfered with the adhesion of cells expressing alphaIIbeta3, alpha1beta1, alpha5beta1, alpha4beta1 alphavbeta3, and alpha9beta1 integrins to other ligands such as fibrinogen, fibronectin, and collagen IV. Alternagin and alternagin-C also mediated the adhesion of the K562-alpha2beta1-transfected cells. Our results show that the disintegrin-like domain of alternagin is responsible for its ability to inhibit collagen binding to alpha2beta1 integrin."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.org/dc/terms/identifier | "doi:10.1006/abbi.2000.2120"xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.org/dc/terms/identifier | "doi:10.1006/abbi.2000.2120"xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Zingali R.B."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Zingali R.B."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Oliva M.L.V."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Oliva M.L.V."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Niewiarowski S."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Niewiarowski S."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Selistre-de-Araujo H.S."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Selistre-de-Araujo H.S."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Souza D.H.F."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Souza D.H.F."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Faria J.P."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Faria J.P."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Ferreira L.L."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Ferreira L.L."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Iemma M.R.C."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/author | "Iemma M.R.C."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/name | "Arch. Biochem. Biophys."xsd:string |
| http://purl.uniprot.org/citations/11368322 | http://purl.uniprot.org/core/name | "Arch. Biochem. Biophys."xsd:string |