| http://purl.uniprot.org/citations/11368757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11368757 | http://www.w3.org/2000/01/rdf-schema#comment | "Scavenger receptor class B, type I (SR-BI) is expressed in the intestines of rodents and has been suggested to be involved in the absorption of dietary cholesterol. The aim of this study was to determine whether intestinal SR-BI expression is affected in animal models with altered bile delivery to the intestine and impaired cholesterol absorption. SR-BI protein and mRNA levels were determined in proximal and distal small intestine from control, bile-duct-ligated and bile-diverted rats and from control and bile-duct-ligated mice. Two genetically altered mouse models were studied: multidrug resistance-2 P-glycoprotein-deficient [Mdr2((-/-))] mice that produce phospholipid/cholesterol-free bile, and cholesterol 7alpha-hydroxylase-deficient [Cyp7a((-/-))] mice, which exhibit qualitative and quantitative changes in the bile-salt pool. Cholesterol-absorption efficiency was quantified using a dual-isotope ratio method. SR-BI was present at the apical membrane of enterocytes in control rats and mice and was more abundant in proximal than in distal segments of the intestine. In bile-duct-ligated animals, levels of SR-BI protein were virtually absent and mRNA levels were decreased by approximately 50%. Bile-diverted rats, Mdr2((-/-)) mice and Cyp7a((-/-)) mice showed decreased levels of intestinal SR-BI protein while mRNA levels were unaffected. Cholesterol absorption was reduced by >90% in bile-duct-ligated and bile-diverted animals and in Cyp7a((-/-)) mice, whereas Mdr2((-/-)) mice showed an approximately 50% reduction. This study shows that SR-BI is expressed at the apical membrane of enterocytes of rats and mice, mainly in the upper intestine where cholesterol absorption is greatest, and indicates that bile components play a role in post-transcriptional regulation of SR-BI expression. Factors associated with cholestasis appear to be involved in transcriptional control of intestinal SR-BI expression. The role of SR-BI in the cholesterol-absorption process remains to be defined."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.org/dc/terms/identifier | "doi:10.1042/0264-6021:3560317"xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/author | "Schwarz M."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/author | "Groen A.K."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/author | "Kuipers F."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/author | "Rigotti A."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/author | "Voshol P.J."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/author | "Krieger M."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/pages | "317-325"xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/title | "Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine."xsd:string |
| http://purl.uniprot.org/citations/11368757 | http://purl.uniprot.org/core/volume | "356"xsd:string |
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