http://purl.uniprot.org/citations/11368848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11368848 | http://www.w3.org/2000/01/rdf-schema#comment | "The Rho-GDP dissociation inhibitor (Rho-GDI) was used as bait in a two-hybrid screen of a human leucocyte cDNA library. Most of the isolated cDNAs encoded GTPases of the Rho subfamily: RhoA, B, C, Rac1, 2, CDC42 and RhoG. The newly discovered RhoH interacted very poorly with Rho-GDI. Another protein partner shared a homology with RhoA that points to Asp67(RhoA)-Arg68(RhoA)-Leu69(RhoA) as critical for interaction with Rho-GDI. A second screen with RhoA as bait led to the isolation of GDI only. In order to investigate the relative role of protein-protein and protein-lipid interactions between Rho GTPases and Rho-GDI, CAAX box mutants of RhoA were produced. They were found to interact with Rho-GDI as efficiently as wild type RhoA, indicating that protein-protein interactions alone lead to strong binding of the two proteins. The C-terminal polybasic region of RhoA was also shown to be a site of protein-protein interaction with Rho-GDI."xsd:string |
http://purl.uniprot.org/citations/11368848 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0300-9084(01)01263-9"xsd:string |
http://purl.uniprot.org/citations/11368848 | http://purl.uniprot.org/core/author | "Faure J."xsd:string |
http://purl.uniprot.org/citations/11368848 | http://purl.uniprot.org/core/author | "Dagher M.C."xsd:string |
http://purl.uniprot.org/citations/11368848 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11368848 | http://purl.uniprot.org/core/name | "Biochimie"xsd:string |
http://purl.uniprot.org/citations/11368848 | http://purl.uniprot.org/core/pages | "409-414"xsd:string |
http://purl.uniprot.org/citations/11368848 | http://purl.uniprot.org/core/title | "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)."xsd:string |
http://purl.uniprot.org/citations/11368848 | http://purl.uniprot.org/core/volume | "83"xsd:string |
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