| http://purl.uniprot.org/citations/11373622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11373622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11373622 | http://www.w3.org/2000/01/rdf-schema#comment | "In the elongation cycle of protein biosynthesis, the nucleotide exchange factor eEF1Balpha catalyzes the exchange of GDP bound to the G-protein, eEF1A, for GTP. To obtain more information about the recently solved eEF1A-eEF1Balpha structure, we determined the structures of the eEF1A-eEF1Balpha-GDP-Mg2+, eEF1A-eEF1Balpha-GDP and eEF1A-eEF1Balpha-GDPNP complexes at 3.0, 2.4 and 2.05 A resolution, respectively. Minor changes, specifically around the nucleotide binding site, in eEF1A and eEF1Balpha are consistent with in vivo data. The base, sugar and alpha-phosphate bind as in other known nucleotide G-protein complexes, whereas the beta- and gamma-phosphates are disordered. A mutation of Lys 205 in eEF1Balpha that inserts into the Mg2+ binding site of eEF1A is lethal. This together with the structures emphasizes the essential role of Mg2+ in nucleotide exchange in the eEF1A-eEF1Balpha complex."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.org/dc/terms/identifier | "doi:10.1038/88598"xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.org/dc/terms/identifier | "doi:10.1038/88598"xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Kinzy T.G."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Kinzy T.G."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Nyborg J."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Nyborg J."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Pedersen L."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Pedersen L."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Andersen G.R."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Andersen G.R."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Valente L."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/author | "Valente L."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/pages | "531-534"xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/pages | "531-534"xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/title | "Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/title | "Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex."xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11373622 | http://purl.uniprot.org/core/volume | "8"xsd:string |