http://purl.uniprot.org/citations/11376627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11376627 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function.MethodsA myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured.ResultsNo significant difference in cardiac function was found between infarcted wildtype and knock-out animals, despite a marked reduction in capillarization and blunting of the hypertrophic response of the interventricular septum in the IGF-1 deficient group. Furthermore, decreased DNA synthesis and increased apoptosis rates were observed in the IGF-1 knock-out mice.ConclusionIGF-1 deficient mice show preservation of cardiac function 1 week after MI, despite an altered cardiac remodeling process."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0008-6363(01)00237-1"xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Kockx M."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "van der Zee R."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Bronsaer R."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Doevendans P.A."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Daemen M.J."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Smits J.F."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Dassen W.R."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Palmen M."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/author | "Zandbergen H.R."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/name | "Cardiovasc Res"xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/pages | "516-524"xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/title | "Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice."xsd:string |
http://purl.uniprot.org/citations/11376627 | http://purl.uniprot.org/core/volume | "50"xsd:string |
http://purl.uniprot.org/citations/11376627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11376627 |
http://purl.uniprot.org/citations/11376627 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11376627 |
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http://purl.uniprot.org/uniprot/#_E9Q138-mappedCitation-11376627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11376627 |
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http://purl.uniprot.org/uniprot/#_P05017-mappedCitation-11376627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11376627 |
http://purl.uniprot.org/uniprot/#_Q4VJC0-mappedCitation-11376627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11376627 |