| http://purl.uniprot.org/citations/11389840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11389840 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11389840 | http://www.w3.org/2000/01/rdf-schema#comment | "The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3beta, forms a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of beta-catenin by the proteasome. Siah-1, the human homolog of Drosophila seven in absentia, is a p53-inducible mediator of cell cycle arrest, tumor suppression, and apoptosis. We have now found that Siah-1 interacts with the carboxyl terminus of APC and promotes degradation of beta-catenin in mammalian cells. The ability of Siah-1 to downregulate beta-catenin signaling was also demonstrated by hypodorsalization of Xenopus embryos. Unexpectedly, degradation of beta-catenin by Siah-1 was independent of GSK3beta-mediated phosphorylation and did not require the F box protein beta-TrCP. These results indicate that APC and Siah-1 mediate a novel beta-catenin degradation pathway linking p53 activation to cell cycle control."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00241-6"xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(01)00241-6"xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Stevens J."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Stevens J."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "White R.L."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "White R.L."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Yost H.J."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Yost H.J."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Matsunami N."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Matsunami N."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Neufeld K.L."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Neufeld K.L."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Rote C.A."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/author | "Rote C.A."xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11389840 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |