| http://purl.uniprot.org/citations/11389899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11389899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11389899 | http://www.w3.org/2000/01/rdf-schema#comment | "The hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcription factor for cellular responses to oxygen tension. It is rapidly degraded under normoxic conditions by the ubiquitin-dependent proteasome pathway. Here we report a critical role of the 20S proteasome subunit PSMA7 in HIF-1alpha regulation. PSMA7 was found to interact specifically with two subdomains of HIF-1alpha. PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1alpha activity is associated with the proteasome pathway."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(01)02499-1"xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(01)02499-1"xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Cho S."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Cho S."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Kim J.M."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Kim J.M."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Choi Y.J."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Choi Y.J."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Ryu S.E."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Ryu S.E."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Jeong S.T."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/author | "Jeong S.T."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/pages | "62-66"xsd:string |
| http://purl.uniprot.org/citations/11389899 | http://purl.uniprot.org/core/pages | "62-66"xsd:string |