| http://purl.uniprot.org/citations/11395037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11395037 | http://www.w3.org/2000/01/rdf-schema#comment | "Backgroundfavorable lipid profiles including low total serum cholesterol (TC), TC/HDL-cholesterol (HDL-C) ratio and elevated HDL-C levels have been previously reported in Chinese living in China. More recent data, however, suggests a changing trend toward decreased HDL-C and increased TC and LDL cholesterol (LDL-C) in Chinese populations. Environmental factors likely contribute, in part, to these findings. However, genetic factors contributing to lipoprotein metabolism may also play a role in determining the lipid/lipoprotein phenotype observed in Chinese populations. Lipoprotein lipase (LPL) mutations have been associated with altered HDL-C concentrations in Caucasians but have not yet been studied in a large population of Chinese descent.Methods1577 Chinese Canadians of Cantonese descent were recruited for a cardiovascular risk factor study. The frequency and effect of three LPL gene polymorphisms [Asp9Asn (D9N, n=374), Asn291Ser (N291S, n=321) and Ser447-Ter (S447X, n=403)] on serum HDL-C concentrations was assessed. All the three polymorphisms have been shown to alter HDL-C levels in different Caucasian populations.Resultslower TC, LDL-C, and TG and higher HDL-C were observed in both male and female Chinese Canadian subjects compared to other population samples. The D9N and N291S LPL polymorphisms were identified in 1/374 (0.3%) and 5/321 (1.6%) subjects, respectively. Carrier frequency of the S447X mutation was (102/403) 25.3%. This S447X polymorphism was observed with higher frequency in males with HDL-C levels in the highest tertile compared with those in the lowest HDL-C tertile (carrier frequencies 37.3 vs. 19.4%) (P=0.046).Conclusionin this cohort of Chinese Canadians, the serum lipid profiles were more favorable than what has been reported for Caucasian Canadians. A favorable spectrum of polymorphisms in the LPL gene may mitigate the adverse effects of western lifestyle on plasma lipoproteins in this cohort of Cantonese Canadians."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9150(00)00670-5"xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/author | "Clee S.M."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/author | "Hayden M.R."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/author | "Pimstone S.N."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/author | "Frohlich J.J."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/author | "Bowden J.F."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/author | "McGladdery S.H."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/name | "Atherosclerosis"xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/pages | "401-407"xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/title | "Common mutations in the lipoprotein lipase gene (LPL): effects on HDL-cholesterol levels in a Chinese Canadian population."xsd:string |
| http://purl.uniprot.org/citations/11395037 | http://purl.uniprot.org/core/volume | "156"xsd:string |
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