| http://purl.uniprot.org/citations/11396616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11396616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11396616 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin C is essential for many enzymatic reactions and also acts as a free radical scavenger. Specific non-overlapping transport proteins mediate the transport of the oxidized form of vitamin C, dehydroascorbic acid, and the reduced form, L-ascorbic acid, across biological membranes. Dehydroascorbic acid uptake is via the facilitated-diffusion glucose transporters, GLUT 1, 3 and 4, but under physiological conditions these transporters are unlikely to play a major role in the uptake of vitamin C due to the high concentrations of glucose that will effectively block influx. L-ascorbic acid enters cells via Na+-dependent systems, and two isoforms of these transporters (SVCT1 and SVCT2) have recently been cloned from humans and rats. Transport by both isoforms is stereospecific, with a pH optimum of approximately 7.5 and a Na+:ascorbic acid stoichiometry of 2:1. SVCT2 may exhibit a higher affinity for ascorbic acid than SVCT1 but with a lower maximum velocity. SVCT1 and SVCT2 are predicted to have 12 transmembrane domains, but they share no structural homology with other Na+ co-transporters. Potential sites for phosphorylation by protein kinase C exist on the cytoplasmic surface of both proteins, with an additional protein kinase A site in SVCT1. The two isoforms also differ in their tissue distribution: SVCT1 is present in epithelial tissues, whereas SVCT2 is present in most tissues with the exception of lung and skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.org/dc/terms/identifier | "doi:10.1080/09687680110033774"xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.org/dc/terms/identifier | "doi:10.1080/09687680110033774"xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/author | "Johnson D."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/author | "Liang W.J."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/author | "Liang W.J."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/author | "Jarvis S.M."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/author | "Jarvis S.M."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/name | "Mol. Membr. Biol."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/name | "Mol. Membr. Biol."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/pages | "87-95"xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/pages | "87-95"xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/title | "Vitamin C transport systems of mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/title | "Vitamin C transport systems of mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/11396616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11396616 |
| http://purl.uniprot.org/citations/11396616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11396616 |
| http://purl.uniprot.org/citations/11396616 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11396616 |
| http://purl.uniprot.org/citations/11396616 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11396616 |