| http://purl.uniprot.org/citations/11396961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11396961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11396961 | http://www.w3.org/2000/01/rdf-schema#comment | "The functions of AML1 in hematopoietic differentiation are repressed by AML1-mutants including the AML1/ETO chimeric protein, which is seen in t(8;21) acute myeloid leukemia. Erythroid progenitors of the patients with t(8;21) AML expressed AML1/ETO. To investigate the effect of AML1/ETO in erythroid cells, we made a tetracycline-regulated AML1/ETO overexpression system in mouse erythroleukemic (MEL) cells. Enforced AML1/ETO repressed the terminal erythroid differentiation. Furthermore, we performed representational difference analysis using this MEL cell system to clone the downstream targets of AML1 in erythroid cell differentiation. We cloned a novel transmembrane protein, Art-1 (AML1-regulated transmembrane protein 1), which is a member of tetramembrane spanning superfamily. Art-1 expression was restricted in hematopoietic cells. It was upregulated by AML1 and downregulated by AML1/ETO in both erythroid and myeloid cells, and increased during erythroid cell differentiation. Art-1 may play an important role in the differentiation of erythroid cells, possibly as a direct downstream target of AML1."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.5005"xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.2001.5005"xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Kimura A."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Kimura A."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Harada H."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Harada H."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Harada Y."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Harada Y."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Downing J.R."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/author | "Downing J.R."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/pages | "714-722"xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/pages | "714-722"xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/title | "A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by aml1."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/title | "A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by aml1."xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/11396961 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11396961 |
| http://purl.uniprot.org/citations/11396961 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11396961 |