| http://purl.uniprot.org/citations/11404325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11404325 | http://www.w3.org/2000/01/rdf-schema#comment | "We have shown that the spt6-140 and spt4-3 mutations, affecting chromatin structure and transcription, stimulate recombination between inverted repeats by a RAD52-dependent mechanism that is very efficient in the absence of RAD51, RAD54, RAD55, and RAD57. Such a mechanism of recombination is RAD1-RAD59-dependent and yields gene conversions highly associated with the inversion of the repeat. The spt6-140 mutation alters transcription and chromatin in our inverted repeats, as determined by Northern and micrococcal nuclease sensitivity analyses, respectively. Hyper-recombination levels are diminished in the absence of transcription. We believe that the chromatin alteration, together with transcription impairment caused by spt6-140, increases the incidence of spontaneous recombination regardless of whether or not it is mediated by Rad51p-dependent strand exchange. Our results suggest that spt6, as well as spt4, primarily stimulates a mechanism of break-induced replication. We discuss the possibility that the chromatin alteration caused by spt6-140 facilitates a Rad52p-mediated one-ended strand invasion event, possibly inefficient in wild-type chromatin. Our results are consistent with the idea that the major mechanism leading to inversions might not be crossing over but break-induced replication followed by single-strand annealing."xsd:string |
| http://purl.uniprot.org/citations/11404325 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/158.2.597"xsd:string |
| http://purl.uniprot.org/citations/11404325 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/11404325 | http://purl.uniprot.org/core/author | "Malagon F."xsd:string |
| http://purl.uniprot.org/citations/11404325 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11404325 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11404325 | http://purl.uniprot.org/core/pages | "597-611"xsd:string |
| http://purl.uniprot.org/citations/11404325 | http://purl.uniprot.org/core/title | "Yeast spt6-140 mutation, affecting chromatin and transcription, preferentially increases recombination in which Rad51p-mediated strand exchange is dispensable."xsd:string |
| http://purl.uniprot.org/citations/11404325 | http://purl.uniprot.org/core/volume | "158"xsd:string |
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