| http://purl.uniprot.org/citations/11408477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11408477 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic protein (BMP)-2 has been shown to induce ectopic expression of cardiac transcription factors and beating cardiomyocytes in non-precardiac mesodermal cells, suggesting that BMP-2 is an inductive signaling molecule that participates in cardiac development. However, direct evidence of the effects of BMP-2 on cardiac myocytes has not been reported. To examine the role of BMP-2 and its receptors, we studied the ability of BMP-2 to promote survival of isolated neonatal rat cardiac myocytes. BMP receptors IA, IB, and II and activin receptor I were found to be expressed in myocytes, and BMP-2 phosphorylated Smad1 and p38 MAPK. Interestingly, BMP-2 promoted survival and inhibited apoptosis of serum-deprived myocytes, although it did not strongly induce hypertrophic growth. To explore the mechanisms for this protective effect, an adenovirus-based vector system was used. Similar to BMP-2, Smad1 promoted survival that was repressed by Smad6. Moreover, BMP-2 and Smad1 enhanced the expression of the anti-apoptotic molecule Bcl-x(L). Antisense oligonucleotides to bcl-x(L) attenuated the survival effected by BMP-2. Overall, our findings suggest that BMP-2 prevents apoptosis of myocytes by induction of Bcl-x(L) via a Smad1 pathway and might be a novel survival factor without any hypertrophic effect on myocytes."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m101463200"xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Oshima Y."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Kishimoto T."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Negoro S."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Izumi M."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Hirota H."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Fujio Y."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Yamauchi-Takihara K."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Osugi T."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Nakaoka Y."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Funamoto M."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Kunisada K."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/author | "Tone E."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/pages | "31133-31141"xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/title | "Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway."xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11408477 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11408477 |
| http://purl.uniprot.org/citations/11408477 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11408477 |
| http://purl.uniprot.org/uniprot/P97588#attribution-777B9B550EE4A256077B47A162AE1541 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11408477 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JSQ6-mappedCitation-11408477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11408477 |
| http://purl.uniprot.org/uniprot/#_A0A8I6G8R6-mappedCitation-11408477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11408477 |