| http://purl.uniprot.org/citations/11408484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11408484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11408484 | http://www.w3.org/2000/01/rdf-schema#comment | "Defensins comprise a family of cationic antimicrobial peptides that is characterized by the conserved 6 cysteine residues. They are expressed in the epithelial cells of various organs and are identified as key elements in the host defense system at the mucosal surface. We isolated a novel mouse beta-defensin gene from the bacterial artificial chromosome DNA containing the mouse beta-defensin-3 gene. The full-length cDNA was cloned from skeletal muscle cDNA and called mouse beta-defensin-6 (mBD-6). The predicted peptide conserved the 6-cysteine motif and had 59% amino acid sequence identity with mouse beta-defensin-3 and 59% identity with mouse beta-defensin-4. We demonstrated the expression of mBD-6 in skeletal muscle in addition to the esophagus, tongue, and trachea. In animal models of endotoxemia, mBD-6 expression was also induced in the lung. mBD-6 showed potent antimicrobial activity against Escherichia coli and would play an important role in host defense in the esophagus, airways, and skeletal muscle. mBD-6 is the first reported beta-defensin predominantly expressed in skeletal muscle. This unique tissue specificity suggests some novel physiological roles of this peptide family."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m104149200"xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m104149200"xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Nagase T."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Nagase T."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Tomita T."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Tomita T."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Yamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Yamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Kurihara H."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Kurihara H."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Ouchi Y."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Ouchi Y."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Hitomi S."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/author | "Hitomi S."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11408484 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |