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http://purl.uniprot.org/citations/11412396http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To investigate whether ethanol and isopentanol could modulate the drug metabolism by regulating uridine diphosphate glucuronosyltransferase (UGT) expression in rat livers and cultured rat hepatocytes.

Methods

Rat livers and primary rat hepatocyte cultures have been used to determine the mRNA levels of five UGT isoenzymes following treatment with ethanol and isopentanol.

Results

Following treatment with alcohol in rats, UGT1A1 mRNA and UGT1A5 mRNA were increased to a mean of 177% and 166% of control, respectively. The mRNA levels of UGT2B1 and UGT2B3 were also increased in alcohol-treated rats to 178% and 132% of control, respectively. Incubation of hepatocytes with ethanol and isopentanol significantly increased the mRNA expression of UGT1A1, UGT1A5, UGT2B1 and UGT2B3 mRNA.

Conclusions

The expression of UGT can be regulated by ethanol and isopentanol. As a result, chronic alcohol consumption may modify the metabolism of numerous endogenous and exogenous compounds, in particular some drugs, which are substrates of these UGT isoenzymes."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/author"Zhao B."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/author"Zhang S."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/author"Zhao X."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/author"Wang K."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/author"Yu T."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/name"Zhonghua Gan Zang Bing Za Zhi"xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/pages"172-174"xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/title"[The expression of uridine diphosphate glucuronosyltransferase mRNA regulated by alcohol]."xsd:string
http://purl.uniprot.org/citations/11412396http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/11412396http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11412396
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http://purl.uniprot.org/uniprot/#_P09875-mappedCitation-11412396http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11412396
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