| http://purl.uniprot.org/citations/11413142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11413142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11413142 | http://www.w3.org/2000/01/rdf-schema#comment | "Although little is known about the precise mechanisms by which the molecular chaperone Hsp90 recognizes its client proteins, Cdc37 has been shown to play a critical role in the targeting of Hsp90 to client protein kinases. Described here is the identification and characterization of a novel 35-kDa human protein that is 31% identical to Cdc37. We have named this novel protein Harc (Hsp90-associating relative of Cdc37). Northern blot analysis revealed the presence of Harc mRNA in several human tissues, including liver, skeletal muscle, and kidney. Biochemical fractionation and immunofluorescent localization of epitope-tagged Harc (i.e. FLAG-Harc) indicated that it is present in the cytoplasm of cells. FLAG-Harc binds Hsp90 but unlike Cdc37 does not bind Src family kinases or Raf-1. Mapping experiments indicate that the central 120 amino acids of both Harc and Cdc37 constitute a Hsp90-binding domain not described previously. FLAG-Harc is basally serine-phosphorylated and hyperphosphorylated when co-expressed with an activated mutant of the Src family kinase Hck. Notably, FLAG-Harc forms complexes with Hsp90, Hsp70, p60Hop, immunophilins, and an unidentified p22 protein but not with the Hsp90 co-chaperone p23. Thus Harc likely represents a novel participant in Hsp90-mediated protein folding, potentially targeting Hsp90 to Hsp70-client protein heterocomplexes."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m103889200"xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m103889200"xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/author | "Hall N.E."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/author | "Hall N.E."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/author | "Cartledge K."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/author | "Cartledge K."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/author | "Scholz G.M."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/author | "Scholz G.M."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/pages | "30971-30979"xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/pages | "30971-30979"xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/title | "Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/title | "Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37."xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11413142 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11413142 |
| http://purl.uniprot.org/citations/11413142 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11413142 |
| http://purl.uniprot.org/citations/11413142 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11413142 |
| http://purl.uniprot.org/citations/11413142 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11413142 |