| http://purl.uniprot.org/citations/11418250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11418250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11418250 | http://www.w3.org/2000/01/rdf-schema#comment | "The enzyme myo-inositol monophosphatase (Impa) catalyzes the synthesis of free myo-inositol from various myo-inositol monophosphates in the phosphatidylinositol signaling system. Impa is a lithium-blockable enzyme that has been hypothesized to be the biological target for lithium-salts used as mood-stabilizing drugs in the treatment of manic-depressive (bipolar) illness. As an initial step to explore the functional consequences of reduced or absent Impa activity in an animal model we here report the isolation of two Impa-encoding mouse genes, Impa1 and Impa2. Impa1 spans approximately 17.5 kb and contains nine exons of 46--1354 bp encoding a protein of 277 amino acids. Impa2 spans at least 19.5 kb and contains eight exons of 46--444 bp size encoding a protein of 290 amino acids. The genomic structure including the positions of the exon-intron splice sites seems to be conserved among myo-inositol monophosphatase genes in mammalian species. One or more Impa-like genes do also exist in evolutionary more distant species like invertebrates, plants and bacteria. The proteins encoded by the non-vertebrate genes seem to be equally related to Impa1 and Impa2. We therefore suggest that the Impa1 and Impa2 genes duplicated from a common ancestral gene after the evolutionary divergence of vertebrates."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(01)00502-9"xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-1119(01)00502-9"xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0378-1119(01)00502-9"xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Steen V.M."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Steen V.M."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Agam G."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Agam G."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Shamir A."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Shamir A."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Ebstein R.P."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Ebstein R.P."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Sjoeholt G."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/author | "Sjoeholt G."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/pages | "285-291"xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/pages | "285-291"xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/title | "Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/title | "Characterization of two genes, Impa1 and Impa2 encoding mouse myo-inositol monophosphatases."xsd:string |
| http://purl.uniprot.org/citations/11418250 | http://purl.uniprot.org/core/volume | "271"xsd:string |