| http://purl.uniprot.org/citations/11418864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11418864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11418864 | http://www.w3.org/2000/01/rdf-schema#comment | "Genotoxic stress triggers the activation of checkpoints that delay cell-cycle progression to allow for DNA repair. Studies in fission yeast implicate members of the Rad family of checkpoint proteins, which includes Rad17, Rad1, Rad9 and Hus1, as key early-response elements during the activation of both the DNA damage and replication checkpoints. Here we demonstrate a direct regulatory linkage between the human Rad17 homologue (hRad17) and the checkpoint kinases, ATM and ATR. Treatment of human cells with genotoxic agents induced ATM/ATR-dependent phosphorylation of hRad17 at Ser 635 and Ser 645. Overexpression of a hRad17 mutant (hRad17AA) bearing Ala substitutions at both phosphorylation sites abrogated the DNA-damage-induced G2 checkpoint, and sensitized human fibroblasts to genotoxic stress. In contrast to wild-type hRad17, the hRad17AA mutant showed no ionizing-radiation-inducible association with hRad1, a component of the hRad1-hRad9-hHus1 checkpoint complex. These findings demonstrate that ATR/ATM-dependent phosphorylation of hRad17 is a critical early event during checkpoint signalling in DNA-damaged cells."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.org/dc/terms/identifier | "doi:10.1038/35082110"xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.org/dc/terms/identifier | "doi:10.1038/35082110"xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Ali A."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Ali A."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Fang Y."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Fang Y."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Wang X.-F."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Wang X.-F."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Bao S."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Bao S."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Abraham R.T."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Abraham R.T."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Brumbaugh K.M."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Brumbaugh K.M."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Chen S.M."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Chen S.M."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Richardson D.A."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Richardson D.A."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Tibbetts R.S."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/author | "Tibbetts R.S."xsd:string |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11418864 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |